OXIDATIVE-ANTIOXIDANT SYSTEM IN CANCER PATIENTS

It is known that oncological diseases are accompanied by pronounced disturbances in the main regulatory systems of homeostasis. The most important role in metabolic disorders in patients with malignant tumors belongs to the intensification of lipid peroxidation in the blood serum, activation of free radical processes and imbalance of the antioxidant defense system. Free radicals play a key role at all stages of carcinogenesis in the processes of malignant cell transformation and tumor development.

Active oxygen metabolites can be considered as a universal tool for tumor transformation caused by spontaneous or induced physicochemical factors of carcinogenesis. The accumulation of free radicals and their reaction products puts a significant load on the detoxification system and is one of the causes of general and local toxic reactions.

Free radicals in the body

Antioxidant protection

Antioxidant protection is the background against which all physiological processes are played out. Excessive radical formation under conditions of decompensation of the antioxidant system leads to disturbances in other humoral and cellular systems of the body, the development of oxidative stress.

Antioxidant in detoxification system

The main obstacle in the body on the path of cascade radical formation is the antioxidant link of the detoxification system. It is a branched network of physiologically active compounds that eliminate free radical and peroxide compounds formed both in the process of the body's vital activity in the norm and during the development of various pathological conditions, as well as as a result of tumor aggression or antitumor treatment.